PhD Position in RNA splicing research group

Lokalita

Jihomoravský

Typ nabídky

doktorská práce

Platnost

SKONČENO

Obory
biologie chemie
Zaměstnavatel

CEITEC MU

Popis pozice

We are looking for a highly motivated PhD student to empower our pre-mRNA splicing research group led by ass. prof. MUDr. Tomáš Freiberger, PhD., working at CEITEC MU and at Centre for Cardiovascular Surgery and Transplantation in Brno, Czech Republic. We are studying mechanisms involved in the development of genetically determined immune system disorders, with special focus on mRNA splicing affecting events.

The abstract to the PhD topic:
RNA splicing is an important step in the pre-mRNA processing. It enables diversification of RNA/protein function and subsequent differentiation of cell types via alternative splicing. This process is regulated by RNA-binding factors recognizing RNA sequence motifs. Core binding motifs are conserved exon-intron junctions (acceptor and donor splice sites) and branch point and they bind core spliceosomal components. Recognition of exons/introns is usually supported by other regulators of splicing, that bind exonic and intronic splicing enhancers and silencers. Considering high degeneracy of these motifs and their high context-dependency, it is extremely difficult to predict their presence and their impact on splicing, and it is necessary to evaluate their presence experimentally. Existing assays are laborious and the number of verified sequences is limited. Therefore we developed new next generation sequencing (NGS) method, that is able to evaluate the impact of high number of mutation on RNA splicing. The aim of the PhD project will be to further optimize the method and subsequently to identify gene regions that are fundamental for RNA splicing and therefore also for the development of serious hereditary diseases via splicing aberration. Both classical and NGS approaches will be used to reach this goal.

In case of interest, please send your CV (incl. list of publications) and the letter of motivation, optionally the recommendation letter, to Lucie Grodecká (lucie.grodecka@cktch.cz) before the April 14.

Požadavky

- person with strong background in the field of molecular biology, biochemistry or related subjects; - experience and skills in basic molecular biology techniques (preferably including experimentation with RNA, proteins and cell culture);
- ability to and indulgence in reading scientific literature and presenting his/her own research to others (in English);
- enthusiastic and well-organized colleague willing to collaborate and discuss his/her ideas with other team members

Zaměstnanecké výhody

- dynamic and friendly environment

PhD bursary (standard for Masaryk University, Faculty of Science) plus a part-time job

Požadované vzdělání

Mgr

Adresa

Kamenice 753/5
Brno
62500

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Nabídka vložena 22. 03. 2017 a vyprší 14. 04. 2017

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